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Open access Oct 2026

Role of postoperative radiotherapy in locally advanced esophageal squamous cell carcinoma after neoadjuvant chemoimmunotherapy: A retrospective propensity score-matched study

Although neoadjuvant immunochemotherapy (NCIT) has shown promising prospects in the treatment of locally advanced esophageal squamous cell carcinoma (LA-ESCC), the role of adjuvant radiotherapy in these patients remains unclear. This study aimed to investigate the impact of postoperative adjuvant radiotherap...

Li Li, X. Jing, Ming-Juan Sun et al. · 0 citations
Review Sep 2026

Radiotherapy-induced PD-L1 conversion in esophageal squamous cell carcinoma: From multidimensional mechanisms to clinical rescue strategies.

Esophageal squamous cell carcinoma (ESCC) remains a formidable malignancy, with patients harboring programmed death ligand-1 (PD-L1)-negative tumors frequently exhibiting an "immune desert" phenotype and poor response to immune checkpoint blockade (ICB). Radiotherapy (RT), traditionally utilized for localized cytoreduc...

Yi Ding, Wang Jing, Hui Zhu · 0 citations

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