Integrative multi-omics analysis reveals the PFAS-gut microbiome-FN1 axis in chronic kidney disease: From exposome to therapeutic target.
Per- and polyfluoroalkyl substances (PFAS) are persistent environmental pollutants associated with chronic kidney disease (CKD), yet the molecular mechanisms linking PFAS exposure to renal fibrosis remain incompletely understood. We developed a Chemical-Microbiome-Metabolite-Target-Pathway-Disease (C-M-M-T-P-D) network...