Endogenous metabolite bilirubin suppresses esophageal squamous cell carcinoma by activating PERK-dependent translational repression.
It is found that higher serum bilirubin levels were associated with improved overall survival and served as an independent favorable prognostic factor in ESCC and bilirubin suppresses tumor progression via PERK-mediated translational repression, providing mechanistic insights into the role of the PERK-eIF2α axis in bil...