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Open access Sep 2026

Immunoinformatics-Guided Design, Immunological Evaluation, and Macrophage Transcriptomic Profiling of a Multi-Epitope Vaccine Candidate Against Mycobacterium avium subsp. paratuberculosis

The designed MAP multi-epitope vaccine candidate was immunogenic in mice; the exploratory MYY-containing formulation showed numerically higher immune-response readouts in this experimental setting, although these differences were not statistically significant.

Zhi-Jie Luo, Zeng-Ke Wei, Jia-Luo Xu et al. · 0 citations
Open access Jul 2026

Brucella effector protein BspJ inhibits the NF-κB signaling pathway by targeting the Zfp740 promoter region to promote bacterial survival within macrophages

This study systematically elucidates a novel regulatory axis, BspJ-Zfp740-P65/NF-κB, and reveals a new mechanism by which Brucella directly interferes with host transcriptional programs through a nucleus-targeting effector protein to suppress inflammation and establish persistent infection.

Wen-Jia Wang, Xiaoxiao Cheng, Qianyi Zhang et al. · 0 citations

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