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Open access Sep 2026

Echinocystic acid alleviates cerebral ischemia-reperfusion injury through PPARγ-dependent modulation of microglial polarization and pyroptotic signaling.

Cerebral ischemia-reperfusion injury (CIRI) worsens outcomes after ischemic stroke, yet effective pharmacological interventions remain limited. Echinocystic acid (EA), a pentacyclic triterpenoid isolated from the fruits of Gleditsia sinensis Lam., has shown neuroprotective activity in CIRI, but its direct molecular tar...

Yi Zou, Hui Zhang, Jian-Xia Liu et al. · 0 citations

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