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Open access Sep 2026

Neonatal Sevoflurane Exposure Induces Long‐Term Cognitive Impairment via Epigenetically Mediated MMP9 Activation and Perineuronal Net Disruption in the Hippocampal CA2

ABSTRACT Sevoflurane is one of the most commonly used general anesthetics in pediatric clinical practice worldwide. Although accumulating preclinical evidence indicates that neonatal sevoflurane exposure causes persistent cognitive impairments, the extracellular mechanisms remain unclear. Herein, we focus on perineuron...

Li-Rong Liang, Jia-Chen Wang, Tao-Zhi Wang et al. · 0 citations
Open access Sep 2026

Anterior Cingulate Cortex Astrocytes Regulate Chronic Itch and Comorbid Negative Emotional Disorders in Mice

ABSTRACT Aims The anterior cingulate cortex (ACC) is widely recognized as a key brain region in modulating itch and itch‐associated behaviors. Though neuronal mechanisms are increasingly clarified, the role of ACC astrocytes remains poorly understood. Methods By employing a diphenylcyclopropenone (DCP)‐induced chronic...

Ze Fan, Xiao-Tong Shi, You Wu et al. · 0 citations

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