Artificial Intelligence-Aided De Novo Design of High-Affinity Protein Binders Against Shiga Toxin 2
Shiga toxin-producing Escherichia coli (STEC) is a major food-borne pathogen with limited treatment options. Targeting Shiga toxin (Stx) represents a promising therapeutic strategy. Using artificial intelligence (AI)-assisted de novo protein design combined with bacterial surface display screening, pull-down assays,...