Chamber-Design-Associated In Situ Formation of HepG2 Spheroids in a Perfusable Organ-on-a-Chip.
Perfused spheroid platforms enable continuous mass transport, but the role of chamber architecture in in situ spheroid assembly remains insufficiently understood. Here, we developed a perfusable organ-on-a-chip platform for the in situ formation and culture of HepG2 spheroids and compared rectangle-, rhombus-, and roun...