CRM1-Dependent Cytoplasmic Accumulation of TRIM27 Is Associated with Glomerular Endothelial Cell Injury in Lupus Nephritis
Highlights What are the main findings? In GECs, TRIM27 appears to be exported from the nucleus via CRM1 and may contribute to GEC injury in LN through its involvement in FOXO1 ubiquitination. What are the implications of the main findings? Targeting the TRIM27 Ser493–CRM1 interaction that mediates TRIM27 translocation...