Open access
Jul 2026
Unveiling the molecular and immune heterogeneity across distinct disease activity states of systemic lupus erythematosus through integrative bulk and single-cell transcriptomics
Abstract Objective Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterised by substantial variability in clinical presentations and disease severity. This study aims to investigate the molecular and cellular mechanisms underlying distinct SLE Disease Activity Index (SLEDAI)-defined disease stat...
Chen Shen, Ming-Zhe Guo, Jian Huang et al.
· Lupus Science and Medicine · 0 citations