Aug 2026
Remodeling lipid and mitochondrial homeostasis: a novel mechanism by which polydatin attenuates renal tubular senescence in chronic kidney disease.
PD rewires lipid metabolism, restores mitochondrial homeostasis, and activates the SIRT3/SOD2 axis to mitigate DNA damage and suppress tubular senescence, thereby halting CKD progression and position PD as a promising therapeutic candidate for senescence-associated kidney diseases.
Ting-Ting Wang, Hui Wang, Wenfeng Guo et al.
· International Immunopharmaco... · 0 citations