The deubiquitinase OTUD1 aggravated dopaminergic neurodegeneration in Parkinson's disease model by promoting the degradation of Parkin.
Parkin plays a pivotal role in the pathogenesis of Parkinson's disease (PD). Deubiquitinating enzymes (DUBs), which reverse Parkin ubiquitination, are critical for maintaining mitochondrial homeostasis. Although ovarian tumor protease deubiquitinase 1 (OTUD1) participates in various biological processes, its specific f...