PTGER4 promoter methylation may serve as an independent prognostic biomarker and is associated with response to hypomethylating agents in pediatric acute myeloid leukemia
PTGER4 promoter methylation is a promising prognostic biomarker for pediatric AML and correlates with improved response to HMAs, and could help refine risk stratification and guide individualized treatment decisions, particularly in patients with baseline thrombocytopenia.