ABSTRACT Acquired resistance to gemcitabine (GEM) remains a major barrier to effective treatment of pancreatic ductal adenocarcinoma (PDAC). Here we identify histone H3K18 lactylation (H3K18la), induced by GEM‐driven lactate accumulation, as a key epigenetic mechanism of chemoresistance. H3K18la functions as a transcri...
Li-Jun Zhao, Jian-Zhong Cao, Wen-Yue Liu et al.· Advancement of science· 0 citations
It is reported that TDP-43 acts as a key ferroptosis regulator facilitating LUAD growth, and whole transcriptome sequencing combined with subsequent validation assays revealed that TDP-43 is capable of suppressing ferroptosis in LUAD cells.
This framework highlights that therapeutic paradigms should shift from nonselective TAM depletion to niche-specific metabolic-epigenetic reconstruction, providing a precise roadmap for designing next-generation engineered macrophage therapies.
Li-Jun Zhao, Xu-Yun Li, Wen-Yue Liu et al.· Trends in Molecular Medicine· 0 citations
It is found that the oncogenic effect of mutant p53 in vivo is dependent on the tumor immune microenvironment, and restoration of ALKBH5 activation or inhibition of the m6A modification-YTHDF3 axis could potentially reactivate immune surveillance and eliminate tumors harboring mut-p53.
