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Author

Huiling Zhou

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Review Open access Sep 2026

Molecular design and delivery of extracellular and membrane protein degradation chimeras.

Extracellular and membrane-associated proteins constitute a substantial therapeutic target space that remains largely inaccessible to intracellular degradation strategies based on the ubiquitin-proteasome system. Membrane and extracellular targeted protein degradation (meTPD) addresses this limitation by coupling targe...

Shu-Tong Lin, Hui-Ling Zhou, Jia-Yan Qiu et al. · 0 citations
Jul 2026

Molecular Engineering of Stimuli-Activatable Protein Degraders for Precise Cancer Therapy.

This Account systematically summarizes recent advances regarding the rational design of stimuli-activatable protein degraders, and strategically outline the "when and how" of integrating these degraders with nanomedicine platforms to tailor precise cancer therapy.

Jing Gao, Yi Lai, Bo Hou et al. · 0 citations

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