Engineered Probiotics with Pb-Binding Enhanced Curli Nanofibers for Oral Lead Elimination.
Lead poisoning remains a persistent global health challenge. Current small-molecule chelation therapies for lead poisoning cause systemic side effects due to non-specific metal depletion. Here, we propose an "affinity-selectivity-safety" strategy using a living biointerface in which the probiotic is programmed to overe...