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Author

Hui Li

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Open access 2026

Mitochondrial Capsule Transplantation: Opening a New Chapter in the Treatment of Mitochondrial Diseases and Parkinson’s Disease

Mitochondrial transplantation has significant potential for treating mitochondrial diseases but the application bottleneck lies in how to efficiently deliver exogenous mitochondria to somatic cells or tissues, which continues to be a major challenge. Recently, Du et al. pioneered the use of blood-derived red blood cell...

Hui Li, Qian-Jin Liu · 0 citations
Aug 2026

Leveraging host cell modulators of adeno-associated vectors transduction to tailor viral biodistribution.

A novel approach to detarget liver transduction is developed by transiently downregulating the expression of key entry factors in this tissue using GalNac-siRNAs prior to AAV9 administration, which blunted hepatic transduction but also redirected the vector to other transduction-permissive tissues.

K. Kubek-Luck, J. Velazquez, Xiao-Rui Yao et al. · 0 citations

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