The Biphasic Role of Reactive Oxygen Species in Ovarian Cancer Progression and Therapeutics: Crosstalk Among Metabolism, Ferroptosis, and the Tumor Immune Microenvironment.
A dynamic ROS modulation framework is proposed that advocates for precise, personalized pro-oxidant or antioxidant interventions based on each patient's tumor subtype, real-time redox state, and TIME characteristics, offering a robust translational path for next-generation precision oncology in OC.