Open access
Sep 2026
Targeting the NOTCH1 signaling pathway in chronic lymphocytic leukemia enhances the efficacy of CD19 CAR-T cells
The therapeutic efficacy of chimeric antigen receptor T (CAR-T) cells targeting CD19 in chronic lymphocytic leukemia (CLL) treatment can be limited by target cell antigen loss. This study aims to elucidate how the intrinsic NOTCH1 signaling activity in CLL cells modulates their sensitivity to CD19-targeted CAR-T...
Hui-Jian Zheng, Hua-Jian Xian, Chao-Qun Lu et al.
· Cancer Immunology and Immuno... · 0 citations