Triptolide-loaded MSC membrane nanoparticles with enhanced pulmonary accumulation for the treatment of acute lung injury: from network pharmacology to experimental validation
Acute lung injury (ALI) and its severe form acute respiratory distress syndrome (ARDS) are critical conditions with few effective therapies. Triptolide (TPL), a bioactive compound from Tripterygium wilfordii, exhibits potent anti-inflammatory effects but its clinical use is restricted by poor solubility, rapid clearanc...