Author

Hui-Fern Koay

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Open access Oct 2026

Multidimensional molecular profiling reveals decidual and circulating NK cell dynamics in early and late pregnancy.

BACKGROUND Human pregnancy presents a unique physiological state that allows for growth of an antigenically dissimilar foetus. The immune system plays a key role in establishing and maintaining successful pregnancy, yet detailed understanding of immunological responses in pregnancy is lacking. METHODS We defined the...

Jennifer R. Habel, Thi H. O. Nguyen, L. Allen et al. · EBioMedicine · 0 citations

Sep 2026

Specific targeting of MR1-antigen complexes using nanobodies.

T cell receptor mimic (TCRm) antibodies that bind peptide-human leukocyte antigen complexes have great therapeutic potential. Major histocompatibility complex class I-related protein 1 (MR1) exhibits limited polymorphism and presents conserved metabolites, such as 5-OP-RU, derived from microbial riboflavin biosynthesis...

Hisham S. Hussain, S. Redmond, W. Awad et al. · Science immunology · 0 citations

Open access Sep 2026

γδ T cells modulate anti-tumor immunity in small cell lung cancer.

Small cell lung cancer (SCLC) is a highly aggressive neoplasm with limited sensitivity to anti-PD-(L)1 blockade, which is likely caused by the epigenetic silencing of MHC-I. Elucidating MHC-I-independent immune recognition mechanisms is therefore crucial for enhancing treatment responses and improving clinical outcomes...

Jin Ng, Yue You, Tina Zhang et al. · Cancer Cell · 0 citations