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Hui-Dong Shi

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Open access Sep 2026

Elevated dNTP Pool Levels Impair Homologous Recombination and Enhance Glioblastoma Sensitivity to Irradiation and Temozolomide

It is demonstrated that increasing deoxyribonucleoside triphosphate (dNTP) levels impairs HR-mediated double-strand break repair, rendering GBM cells sensitive to IR and Temozolomide and uncovering a promising vulnerability that could be exploited to overcome resistance to DNA-damaging treatments in GBM and beyond.

Dominique Monroe, Mercy Kehinde-Ige, Arilyn Williams et al. · 0 citations

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