Open access
Aug 2026
CLDN18.2 antibody design with protein language models: A deep learning optimization framework
CLDN18.2 is a promising tumor-specific antigen; however, the development of therapeutic antibodies against it is challenged by the need for simultaneous optimization of affinity and developability. To address this, we present cdrGPT, a deep learning framework based on GPT-2 for de novo generation of complementarity-det...
Tao Qu, Lingyan Yuan, Wei-Ran Cui et al.
· PLoS Computational Biology · 0 citations