Influenza A virus continues to pose pandemic threats, as demonstrated by the recent global spread of highly pathogenic H5N1 strains. Consequently, the development and characterization of vaccines targeting zoonotic influenza subtypes have become a major focus of the field. In this study, we characterize two broadly rea...
Guthrie L. Stroh, Hui-Bin Lv, Chun-Ke Chen et al.· bioRxiv· 0 citations
The highly conserved influenza virus hemagglutinin (HA) stem domain is a major target for broadly neutralizing antibodies (bnAbs). However, despite being discovered more than a decade ago, the IGHV1-69-encoded CR9114 remains the only HA stem bnAb that cross-reacts with both influenza A and B viruses. To investigate the...
Katrine E. Dailey, Yi-Quan Wang, Q. Teo et al.· PLoS Biology· 0 citations
Despite the significant impact of SARS-CoV-2 vaccines in curtailing the spread and severity of COVID-19, comprehensive omics-level understanding of longitudinal host responses remains elusive. We recruited 553 Hong Kong participants receiving two doses of CoronaVac (inactivated virus) or BNT162b2 (mRNA-based). Longit...
H. Tun, Shi-Lin Zhao, Chun-Ke Chen et al.· Cellular and Molecular Life...· 0 citations
The structural basis by which specific mutations enhance cross‐variant recognition of SARS‐CoV‐2 is defined, highlighting the underappreciated breadth encoded within the naïve B‐cell repertoire and providing a conceptual framework for engineering and eliciting antibody responses resilient to future antigenic drift.
Huibin Lv, Ziqi Feng, Q. Teo et al.· Advancement of science· 0 citations
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