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Author

Hugo Boutier

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Open access Aug 2026

Preclinical evaluation of homodimeric FAPI target modules for UniCAR-mediated targeting of FAP-expressing tumor and stromal cells

This work reports the first homodimeric FAP inhibitor (FAPI)-based TMs that enable efficient adapter CAR T-cell immunotherapy of FAP-positive tumors and shows that simultaneous dual-targeting leads to enhanced UniCAR-mediated cytotoxicity.

Hugo Boutier, Simona Mattiussi, L. R. Loureiro et al. · 1 citation
Review Open access Aug 2026

The Evolution of FAP-Targeted CAR T-Cell Therapy in Solid Tumors: From Immunotherapy to Immunotheranostic Applications

Chimeric antigen receptor (CAR) T-cell therapy has revolutionized the treatment landscape of hematologic malignancies but has demonstrated limited efficacy in solid tumors, mainly due to the complex and immunosuppressive tumor microenvironment (TME). Among the strategies to overcome this challenge, targeting the tumor...

Hugo Boutier, A. Feldmann, Michael Bachmann · 0 citations

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