Author

H. C. Hemmings

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Open access Jul 2026

Increased expression of developmental Nav1.3 promotes hippocampal CA3 hyperexcitability in early-stage 5xFAD mice

It is shown that Nav1.3, a subtype normally confined to early development, shows aberrantly increased expression in the dentate gyrus (DG)-CA3 circuit in early-stage 5xFAD mice, which is identified as a driver of early hippocampal network dysfunction in AD.

Jiabin Tang, Cameron Swope, Kishan Patel et al. · bioRxiv · 0 citations