Ferroptosis is an iron-dependent form of regulated cell death driven by membrane lipid peroxidation and has become an important therapeutic vulnerability in cancer. The Hippo pathway, through its transcriptional effectors Yes-associated protein and transcriptional coactivator with PDZ-binding motif, links cell contact,...
Zi-Yi Xu, Ruo-Chen Yang, Huda Akram et al.· Frontiers in Medicine· 0 citations
The biological rationale for ferroptosis-targeted cancer therapy is summarized, major translational barriers are analyzed, and nanomedicine strategies that may move ferroptosis induction from experimental proof of concept toward clinically interpretable intervention are synthesized.
Yan-Pin Ma, Zi-Yi Xu, Huda Akram et al.· Frontiers in Molecular Biosc...· 0 citations
The constructed RSF model offers a promising computational framework for risk stratification and provides hypothesis-generating insights that may inform future personalized treatment strategies for HCC patients, suggesting a profound link with single-cell metabolic‒immune crosstalk.
