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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Huan-Ying Xiong

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Aug 2026

PGK1-driven histone lactylation fuels MDSC-driven immune evasion and tumor progression in triple-negative breast cancer.

Functional assays demonstrated that PGK1-driven glycolysis in TNBC cells promotes lactate accumulation and H3K18la, which subsequently induce transcriptional activation of CCL5 and recruitment of MDSCs, thereby impairing CD8+ T cell function and fostering an immunosuppressive tumor microenvironment that facilitates imm...

Yongpeng Wang, Wen-Zhen Dang, Zhendan Liu et al. · 0 citations

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