ABSTRACT Secondary neuroinflammation drives progressive damage after traumatic brain injury (TBI), but therapeutics that modulate key inflammatory amplifiers remain limited. Here, we identify infiltrating macrophages as the predominant TREM1‐expressing population in TBI human and mouse brain and show that TREM1 deletio...
Yi-Min Huang, Yuan Liu, Huan Peng et al.· Advancement of science· 0 citations
Peptide phage display is a cornerstone technology in molecular engineering, providing a robust platform for the rapid discovery of high-affinity ligands. The rapid rise of peptides, especially in therapeutics, over recent years has shed light on the importance of phage display as a tool for peptide discovery. The evolu...
Belle Li Ling, Huan Peng, T. S. Lim· Biotechnology and Bioenginee...· 0 citations
This chapter describes protocols for the preparation of key reagents, the implementation of a complete phage screening workflow, phage amplification via liquid/plate/OD260 optical density methods, and chemical coupling-based phage surface modification to achieve functionalization, along with critical notes to ensure re...
Ying-Qi Xu, Wei-Xuan Luo, Wen-Li Tong et al.· Methods in molecular biology· 0 citations
This mini review traces the evolution of AI-driven methods in protein research, from early residue-contact prediction using coevolutionary information to transformative breakthroughs, the rise of protein language models (PLMs), and the emerging era of generative design and functional modeling.
Guodong Min, Huan Peng· Methods in molecular biology· 0 citations
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