Open access
Sep 2026
Dynamic states of an MHC class I molecule during peptide exchange
Antigens of intracellular origin are processed then presented by proteins of the highly polymorphic major histocompatibility complex I (MHCI), thereby enabling T cell activation during an immune response. In particular, the peptide-exchange catalyst tapasin (Tsn) plays a critical role in shaping the pool of peptide ant...
Alexandra Mitlehner, Aldo S. Pasos-Trejo, M. Becker et al.
· Nature Communications · 0 citations