Research Progress on Structural and Functional Impairments of the vHipp-mPFC Neural Circuit in CUMS-Induced Depression Rodent Models
Major depressive disorder (MDD) lacks objective neuroimaging biomarkers under DSM-5 and ICD-11 diagnostic criteria, while the ventral hippocampus-medial prefrontal cortex (vHipp-mPFC) circuit dominates reward processing and negative emotion regulation. The NIMH RDoC framework urgently requires circuit-level objective i...