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Huan-Bo Zhang

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Review Open access Sep 2026

Research Progress on Structural and Functional Impairments of the vHipp-mPFC Neural Circuit in CUMS-Induced Depression Rodent Models

Major depressive disorder (MDD) lacks objective neuroimaging biomarkers under DSM-5 and ICD-11 diagnostic criteria, while the ventral hippocampus-medial prefrontal cortex (vHipp-mPFC) circuit dominates reward processing and negative emotion regulation. The NIMH RDoC framework urgently requires circuit-level objective i...

Huan-Bo Zhang · 0 citations

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