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Experimental evidence is provided supporting ISO as a potential therapeutic agent for vascular cognitive impairment by dose-dependently improving cognitive function and attenuated demyelination in white matter regions of BCAS mice.
Multiple sclerosis (MS) is an incurable and progressive inflammatory disease of the central nervous system (CNS) characterized by inflammatory demyelination, chronic axonal damage, and neurodegeneration. Carabrone (CA), a sesquiterpene lactone from the traditional Chinese herb Carpesium abrotanoides L., demonstrates di...
Microglia-targeted RIOK3 knockdown reduced infarct volume, improved early neurological and sensorimotor outcomes, preserved microglial process complexity, and reduced post-ischemic inflammation, and highlight the RIOK-YBX1 axis as a potential therapeutic target for ischemic stroke.
Results indicate that carabrone might act as a modulator of NLRP3 inflammasome activation across multiple inflammatory disease contexts.
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