Ovarian cancer is the deadliest gynecological malignancy due to poor drug targeting, severe toxicity, and an immunosuppressive tumor microenvironment (TME). To address this, a pH/GSH dual-responsive bacterial-nanoparticle system (VNP@BD-Poly) based on attenuated Salmonella VNP20009 (VNP) was developed. A bovine serum a...
Living bacterial therapy offers strong tumor‐targeting and deep penetration into hypoxic regions, but its therapeutic potential is hindered by biosafety risks from bacterial proliferation after treatment. Herein, we designed a trigger‐destructive bacterial system that combines precise tumor targeting with controlla...
An intelligent nanoplatform-GOD-Fe3+&DOX-Membrane@Polymer (GOD-Fe3+&DM@Poly.)-based on reversible addition-fragmentation chain transfer (RAFT) polymerization technology is constructed, establishing a valuable technical framework for the development of multifunctional and stimuli-responsive nanomedicines.
Huai-Bin Yu, Zhuo-Rong Miao, Meng Wang et al.· ACS Applied Bio Materials· 0 citations
In vivo studies in diabetic Sprague-Dawley rats model demonstrated that CC-pMnO2-Vet@PNAA established a coordinated immune-mechanical microenvironment, achieving rapid and scar-free wound healing.
