Hua-Rong Huang

Generation of a glycogen storage disease mouse model with fatty liver and its treatment by PPAR-α agonist bezafibrate

Background Fatty liver is considered the pathological basis for the development of glycogen storage disease type Ia (GSDIa); however, due to the lack of suitable animal models, the mechanism underlying fatty liver development in GSDIa is largely unknown. Methods This study employed surrogate breastfeeding to enable the...