This review systematically examines the mechanisms of major PDBIs in hypertension, focusing on their regulation of vascular function, renin-angiotensin-aldosterone system and sympathetic nervous system, water-salt homeostasis, and target organ protection.
Qiqi Deng, Yonglin Zhang, Jing Pan et al.· Phytotherapy Research· 1 citation
The composition and function of the m6A modification system is summarized, with a focus on its critical roles in skeletal muscle physiology, including satellite cell fate determination, myofiber differentiation and fusion, and energy homeostasis, and the molecular mechanisms by which m6A network dysregulation contribut...
Jie Wang, Haiyan Jiang, Jiacheng Sun et al.· Naunyn-Schmiedeberg's Archiv...· 1 citation
This review systematically elucidates the molecular activation mechanisms of the cGAS–STING pathway and its complex regulatory networks within tumors, with a particular focus on analyzing its dual functions—tumor immune surveillance versus tumor promotion—and the determining factors involved.
Haiyan Jiang, Zhanzhan Li, Xia Li et al.· Frontiers in Pharmacology· 2 citations
The mechanisms of cGAS-STING activation in aging-including mitochondrial DNA leakage, nuclear envelope disruption, and retrotransposon activation-and its role in driving cellular senescence and the senescence-associated secretory phenotype (SASP) are reviewed.
Yutong Wei, Sutong Cai, Ya-Nan Ji et al.· Biochemical Pharmacology· 4 citations
This review systematically elaborates on the key pathological roles and molecular mechanisms of ERS and the triggered UPR in Parkinson's disease and discusses various intervention approaches, their research progress, and associated challenges.
Xin Chen, Zihao Zhao, Xinlei Yao et al.· Biochemical Pharmacology· 6 citations
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