Hua-Li Zhang

Increased METTL1 expression in B cell subsets correlates with disease activity and immunological features in SLE.

HSF1 Protects Against Sepsis by Transcriptionally Upregulating Neutrophil C5aR1 to Enhance Antimicrobial Defense.

Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. The resulting septic shock and multiple organ dysfunction syndrome (MODS) are the primary drivers of mortality. Heat shock factor 1 (HSF1), a master transcription factor regulating cellular stress responses, has been sho...

NINJ1 Defines a Hyperinflammatory Monocyte State Associated with Severe COVID-19

Background/Objectives: Severe coronavirus disease 2019 (COVID-19) is characterized by dysregulated immune activation and excessive inflammation; however, the specific immune cell states that drive disease progression remain incompletely understood. Methods: Here, we integrated single-cell RNA sequencing analysis of per...

IL1R2⁺ Inflammatory Monocytes Contribute to Immune Dysregulation and Predict Mortality in COVID-19.

IL1R2 identifies a highly inflammatory monocyte state associated with COVID-19 immune dysregulation, supporting its potential role as a complementary prognostic biomarker and therapeutic target.