Author

Hua Li

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Review Sep 2026

Comprehensive insights into Astragalus membranaceus polysaccharides: Extraction, structural characteristics, bioactivities, and applications: A review.

This review comprehensively evaluates APS extraction, structural characterization, biological activities, and application, with particular emphasis on the evidence linking preparation-dependent structural variation to biological responses.

Jing Cheng, Qian-Hui Liu, Rui Zhu et al. · International Journal of Bio... · 0 citations

Review Open access Jul 2026

Plant metabolites targeting mitochondrial dysfunction in cardiovascular diseases: pharmacological mechanisms and combination strategies

This review systematically summarises recent advances in natural metabolites and their rational combination strategies for cardiovascular diseases with a particular focus on mitochondrial regulation, highlighting the considerable potential of natural products and their rational combinations as therapeutic strategies fo...

Yuyao Wang, Sisi He, Hua Li et al. · Frontiers in Pharmacology · 0 citations

Aug 2026

Discovery of DCAF16-based PROTACs as SHP2 degraders.

The design and synthesis of SHP2 PROTACs that recruit the DCAF16 E3 ligase for targeted SHP2 degradation are reported that support the potential of SHP2-targeted protein degradation as an alternative strategy to enzymatic inhibition and provide a promising starting point for the further development of SHP2 degraders.

X. Pang, Yuxin Gan, Qing-Yuan Hu et al. · Bioorganic chemistry (Print) · 0 citations