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Review Open access Sep 2026

Endothelium-targeted and untargeted nanoparticle therapies in thromboinflammatory vascular diseases

Abstract Endothelial cells (ECs) line the vasculature and integrate hemodynamic, inflammatory, and metabolic cues that are crucial in maintaining vascular health. Endothelial dysfunction is a driver of thromboinflammatory conditions including atherosclerosis, thrombosis, stroke, and sepsis-induced multiorgan dysfunctio...

Micheal O. Avoseh, Hua Jin, Oscar Moreno et al. · 0 citations
Review Open access Sep 2026

Triptolide-loaded MSC membrane nanoparticles with enhanced pulmonary accumulation for the treatment of acute lung injury: from network pharmacology to experimental validation

Acute lung injury (ALI) and its severe form acute respiratory distress syndrome (ARDS) are critical conditions with few effective therapies. Triptolide (TPL), a bioactive compound from Tripterygium wilfordii, exhibits potent anti-inflammatory effects but its clinical use is restricted by poor solubility, rapid clearanc...

Jia-Hao Liu, Yue Zhao, Yi-Xin Zhuang et al. · 0 citations

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