Open access
Oct 2026
A neuronal GPCR modifies neuropeptide signaling to suppress proteostasis in distal tissues
The proteostasis network (PN) safeguards the integrity of proteins by promoting various cellular activities. However, with aging, the PN’s competence declines and aggregated proteins accrue within cells. This process underlies the development of neurodegenerative disorders such as Alzheimer’s and Huntington’s diseases....
Joud Hirbawi, Adam Zaretsky, Hua-Dong Zhu et al.
· Science Advances · 0 citations