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Hu-Ji Xu

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Open access Oct 2026

SEEKER: A genome-scale library-on-library screening platform for deciphering T cell recognition of antigen

Decoding which antigens activate a given T cell receptor (TCR) is a central challenge in immunology. We present SEEKER, a functional genome-scale library-on-library screening platform built on three elements: a Jurkat-derived T-APC cell (TAPCell) that combinatorially expresses one TCR and one peptide–MHC drawn from sep...

Si-Cheng Li, Li Lin, Wen-Xu Wu et al. · 0 citations
Aug 2026

In vivo CAR‑T therapy: recent progress and future directions

In vivo CAR-T is poised to broaden the reach of cellular immunotherapy, provided that its development is guided by rigorous pharmacology, chemistry, manufacturing and controls, and long-term molecular safety surveillance.

Wan-Ting Wang, Yujia Cai, Xuanming Yang et al. · 0 citations

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