Hristo Ivanov

JAK2 V617F Clonal Dynamics from Clonal Hematopoiesis to Myeloproliferative Neoplasms: A Systems Biology Review of Digital PCR-Based Molecular Monitoring

Clonal hematopoiesis of indeterminate potential (CHIP) is an age-associated premalignant state defined by somatic mutations in hematopoietic cells at a variant allele frequency (VAF) ≥2% in the absence of overt hematologic malignancy. Among CHIP-associated mutations, JAK2 V617F is of particular interest because it occu...