Author

Howard Y. Chang

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Open access Sep 2026

Spatiotemporal lineage tracing reveals the dynamic spatial architecture of tumor growth and metastasis

Tumor progression is driven by dynamic interactions between cancer cells and their surrounding microenvironment. Here we integrate high-resolution spatial transcriptomics and evolving lineage-tracing technologies to elucidate how tumor expansion, plasticity and metastasis co-evolve with microenvironmental remodeling in...

Matthew G. Jones, Da-Wei Sun, Kyung Hoi (Joseph) Min et al. · Nature Genetics · 0 citations

Open access Sep 2026

Inverted logic of ecDNA localization converts nuclear periphery into oncogenic transcription hubs in cancer

It is shown that ecDNAs, in contrast to chromosomal DNA, preferentially localize to the nuclear periphery yet resist peripheral gene silencing, and single-molecule multi-omic sequencing and imaging-based CRISPR screening demonstrate enhanced ecDNA hub formation, H3K27ac and H3K9me3 bivalency, late DNA replication, long...

Yan-Bo Wang, Xiao-Wei Yan, Natasha E. Weiser et al. · bioRxiv · 0 citations

Jul 2026

Somatic mutations reveal the ontogeny of microglia in human ageing.

An approach that uses the collection of accumulated somatic mutations that uniquely labels each clone of cells to track the infiltration of bone-marrow-derived cells into the human brain finds evidence of an influx of bone-marrow-derived cells into the brain in all examined individuals.

Julia A. Belk, Yao-Wen Zhang, Emily E. Reilly et al. · Nature · 2 citations