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Author

Hou-Ming Yu

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Sep 2026

Tuberostemonine produces antidepressant effects via the BDNF/TrkB/Erk/CREB signaling pathway.

Depression is a highly prevalent, debilitating psychiatric disorder that imposes severe global public health and socioeconomic burdens, greatly compromising patients' quality of life and social function. Current clinical antidepressants suffer from several critical drawbacks, including delayed therapeutic onset, limite...

Fan Chen, Li-Wei Li, Xiao-Xia Xu et al. · 0 citations
Open access Jul 2026

Tuberostemonine ameliorates Alzheimer’s disease pathology by suppression of the p38 MAPK signaling pathway

Summary Alzheimer’s disease (AD) is a multifactorial neurodegenerative disorder with limited therapeutic options. Here, we report that tuberostemonine (Tub), an alkaloid from Stemona tuberosa, exerts neuroprotective effects in AD models. In Aβ1-42-treated PC12 cells, Tub reduced cytotoxicity, apoptosis, and oxidative s...

Yingzhou Li, Xiaoxia Xu, Ziyao Meng et al. · 0 citations

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