Sep 2026
Mutation rate heterogeneity biases variant effect prediction and reveals genuine mutational robustness.
The findings show that mutation rate heterogeneity systematically biases current variant effect prediction frameworks, highlight the need to model mutation probabilities explicitly in future VEPs, and reveal a genuine biological signal of mutational robustness.
Hossameldin Loay, Prathitha Kar, Evan Koch et al.
· American Journal of Human Ge... · 0 citations