Disulfide-crosslinked triblock polyampholyte vesicles as a reducible platform for polyplex-based nucleic acid delivery.
Polyion complex (PIC) vesicles are attractive carriers for mRNA delivery, yet their assembly is often compromised by charged cargos that disrupt the electrostatic interactions required for vesicle formation. Here, we report triblock polyampholyte vesicles (TBPVs) that encode preferential polymer-polymer interactions, e...