Oct 2026
Berberine increases the sensitivity of sorafenib in human hepatocellular carcinoma via inducing HIF-1α-mediated energy crisis.
BACKGROUND Hepatocellular carcinoma (HCC) often develops resistance to sorafenib (SORA), a multikinase inhibitor that has long been a cornerstone of systemic therapy for advanced HCC, leading to cancer progression and poor survival. Strategies to enhance the therapeutic efficacy of SORA in HCC are therefore urgently ne...
Wei Guo, Zi-Xin Feng, Ming-Hsien Hu et al.
· Phytomedicine · 0 citations