Abstract B076: Tumor cell-intrinsic KMT2D loss regulates T cell function through FN1 signaling in pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest malignancies and is characterized by a profoundly immunosuppressive tumor microenvironment (TME) that limits the efficacy of current therapies. KMT2D (Mll4 in mice) is a histone H3K4 methyltransferase and critical epigenetic regulator that is altere...