Author

Hong Zhu

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Jul 2026

Targeting JOSD2 degrades β-catenin to suppress colorectal cancer metastasis by disrupting RAS/ERK/β-catenin axis.

Findings identify JOSD2 as a critical oncogenic factor that promotes β-catenin activity and validate JOSD2 as an underlying therapeutic target for metastatic CRC (mCRC) both in vitro and in vivo.

Yue Liu, Shuyu Yang, Wen-Han Zhang et al. · Acta Pharmacologica Sinica · 0 citations

Review Jul 2026

Targeted protein degradation: bridging chemical biology and clinical translation.

An overview of the developmental trajectory of the TPD field is provided and how diverse modalities can be leveraged to address intracellular, membrane-associated, and extracellular protein targets are discussed.

Yu-bo Zhang, Junwei Fu, Yue Liu et al. · Acta Pharmacologica Sinica · 0 citations