Author

Hong-Yu Li

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Review Open access Sep 2026

The Role of Thrombospondin-2 in Myocardial Fibrosis

Abstract Myocardial fibrosis is a common pathophysiological process observed in various cardiac diseases and cardiac aging, characterized by excessive accumulation of extracellular matrix proteins in the cardiac interstitium. This process is highly heterogeneous and dynamic, depending on the underlying cardiac patholog...

Wang Guo, Jie-Fen Pu, Hong-Xin Li et al. · Drug Design, Development and... · 0 citations

Review Aug 2026

Stroke Heart Syndrome: Neuroimmune and Metabolic Crosstalk with Conceptual Approaches for Precision Therapeutics.

This review proposes a hypothesis-generating conceptual framework that categorizes SHS into three endophenotypes, including neurogenic arrhythmic (Type I), inflammatory thrombotic (Type II), and metabolic remodeling (Type III), and potential phenotype-specific interventions include beta blockers for neural stabilizatio...

Qiwen Nie, Wang Guo, Zhi-Hao Wang et al. · Cardiovascular Drugs and The... · 1 citation