Sep 2026
Estrogen relieved chronic pain-triggered cognitive dysfunction via restraining excessive inhibition in PV interneurons related to neuroinflammation.
BACKGROUND Clinical studies showed that chronic pain conditions affected patients' cognitive function, but the specific mechanism remained unclear. Animal experiments revealed that compared with female mice, male mice experiencing chronic pain were more prone to hippocampal neuroinflammation and cognitive dysfunction....
Xiao-Xiang Tan, Yu-Zhou Chen, Hong-Yu Dai et al.
· Neurochemistry International · 0 citations